Studying the mechanisms of ribosomes, riboswitches, and LncRNAs.
The Sanbonmatsu team uses computational and experimental approaches to understand the mechanism of a diverse array of non-coding RNA systems, including ribosomes, riboswitches and long non-coding RNAs. Originally focusing on large-scale simulations of the ribosome, we have expanded into joint computational/experimental studies of riboswitches and purely experimental studies of long non-coding RNAs. The ribosome is one of the few large RNA systems that has been studied mechanistically. We are applying our knowledge gained from ribosome studies to long non-coding RNA systems.
Hawkes, E.J, Hennelly, S.P, Novikova, I.V, Irwin, J.A, Dean, C, and Sanbonmatsu, K.Y. (2016) COOLAIR Antisense RNAs Form Evolutionarily Conserved Elaborate Secondary Structures. Cell Reports, published September 20, 2016. doi:10.1016/j.celrep.2016.08.045. View PDF »
Xue, Z, Hennelly, S.P, Doyle, B, Gulati, A.A, Novikova, I.V, Sanbonmatsu, K.Y, and Boyer, L.A. (2016) A G-Rich Motif in the LncRNA Braveheart Interacts with a Zinc-Finger Transcription Factor to Specify the Cardiovascular Lineage. Molecular Cell, published September 8, 2016. doi:10.1016/j.molcel.2016.08.010. View article »
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